Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study

A Lella; LA Antonucci; R Passiatore; L Bellantuono; P Selvaggi; T Popolizio; G Di Sciascio; A Saponaro; P Ricci; M Altamura; G Blasi; A Rampino; C Vriend; VD Calhoun; K Rootes-Murdy; AL Goldman; I Baeza; J Castro-Fornieles; G Sugranyes; E De la Serna; E Pomarol-Clotet; M Fatjó-Vilas; R Salvador; A Karuk; P Fuentes-Claramonte; DC Glahn; AL Rodrigue; J Blangero; L Wang; T Lee; KE Einenkel; S Hamers; O Gruber; A Preda; YC Chung; S Odkhuu; C Vallée; P Dazzan; M Marcelis; S Michielse; K Brosch; F Stein; I Nenadić; B Straube; F Thomas-Odenthal; T Kircher; S Carruthers; SL Rossell; PJ Sumner; TE Van Rheenen; C Demro; IS Ramsay; SR Sponheim; R Lencer; S Meinert; T Hahn; U Dannlowski; D Grotegerd; M Ciccarelli; F Iasevoli; G Pontillo; GD Pearlson; D Cobia; F Piras; N Banaj; D Vecchio; MEA Barendse; NEM van Haren; HJ Jo; K Sim; Y Quidé; MJ Green; R Slate; G Cecere; W Omlor; S Homan; P Homan; SI Thomopoulos; A Manzari; A Bellomo; JA Turner; TGM van Erp; PM Thompson; A Bertolino; G Pergola

Journal article

Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study

A Lella, LA Antonucci, R Passiatore, L Bellantuono, P Selvaggi, T Popolizio, G Di Sciascio, A Saponaro, P Ricci, M Altamura, G Blasi, A Rampino, C Vriend, VD Calhoun, K Rootes-Murdy, AL Goldman, I Baeza, J Castro-Fornieles, G Sugranyes, E De la Serna Show all

Biological Psychiatry | Published : 2025

DOI: 10.1016/j.biopsych.2025.03.027

Abstract

Background: Structural brain differences in the thalamus and the cortex have been widely reported in schizophrenia (SCZ) relative to neurotypical control individuals (NCs). Most previous studies examined the thalamus as a whole as a single region of interest. In addition, findings in individuals at familial high risk for SCZ (FHRs) remain inconclusive. Here, we investigated whether local and network-wide thalamic-related structural alterations vary as a function of familial risk for SCZ. Methods: Structural magnetic resonance imaging scans were obtained from 5197 participants (NC, n = 3409; FHR, n = 257; SCZ, n = 1531) across 32 cross-sectional samples within the ENIGMA (Enhancing Neuro Imag..

View full abstract